What comes next after a positive result?

What comes next after a positive BCL6 result depends on your symptoms and priorities – particularly whether you’re seeking pain relief, fertility support, or both.

Pain and symptom management

For those dealing with chronic pain and other symptoms of endometriosis, treatment is typically centered around long-term management.

This may involve a combination of hormonal therapies including birth control pills or low dose GnHR agonists like leuprolide (Lupron), goserelin (Zoladex), or GnRH antagonists like Elagolix or Relogolix. All these hormone-suppressing drugs are designed to reduce estrogen production which feeds endometriosis.

Other treatment modalities include pain relief medications like Tylenol centered on reducing inflammation, physical therapy and lifestyle-based approaches like anti-inflammatory diets or acupuncture.

The goal here is to reduce daily discomfort by reducing inflammation through hormone suppression or surgery thus improving quality of life, and preventing the condition from worsening over time.

Fertility planning

If fertility is the priority, the focus shifts to creating the most optimal window for conception. Treatment is less about pain, but successfully getting pregnant and having a baby.

The medical approach is the same as pain, but the duration is much shorter and dosage a bit higher. The goal is to reduce the inflammation with either prescribed hormone-suppressing medications, or surgically removing the obstructing endometriosis around the uterine lining through laparoscopic surgery.

If you are going through assisted reproductive treatments like IVF, your doctor may try an embryo transfer without treatment. But if you have failed once or have a history of multiple miscarriages and are positive for BCL6, most women opt to be treated.

However if you are trying to conceive naturally and aren’t ready to see a reproductive specialist, the MyReceptiva test is the way to go and your OB can prescribe either of these approaches without the expense of IVF.

Common post-test options for fertility include:

• GnRH agonists (e.g Lupron) 60Days through 2 -30 day injections
• GnRH antagonists (e.g. Elagolix) 60Days through day pills
• Surgery through laparoscopy
  

You usually don’t need to repeat the test after treatment unless your provider recommends it for specific reasons.

Can the Receptiva test detect adenomyosis?

Not directly, but here’s where it gets interesting. Adenomyosis can sometimes trigger a positive BCL6 result due to inflammation in the surrounding tissue. If your BCL6 is high and adenomyosis is suspected, a follow-up 3D transvaginal ultrasound can provide clarity.

Why isn’t MyReceptiva used outside of fertility treatment more often? Is it approved for general gynecological use?

The test was not offered outside of IVF centers until this year (2025) – mainly because the original use of the test was to identify endometriosis in patients who were navigating IVF failure. 

After doing over 40,000 biopsies and collecting thousands of results and outcomes, the test is now available to the broader population. 

The test kit can be ordered directly by you, as the patient, which reduces the likelihood that your concerns about having endometriosis will be dismissed, or that it won’t be covered. All your doctor has to do is take the biopsy, which is a standard gynecologic procedure.